| DB ID | MyCo_4151 |
| Title | Peripheral blood CD4 + T-lymphocyte counts during Pneumocystis carinii pneumonia in immunocompromised patients without HIV infection |
| Year | 2000 |
| PMID | 10988193 |
| Fungal Diseases involved | Pneumocystis carinii pneumonia |
| Associated Medical Condition | Immunocompromised Patients Without HIV-AIDS Infection |
| Genus | Pneumocystis |
| Species | carinii |
| Organism | Pneumocystis carinii |
| Ethical Statement | A prospective observational study was performed on consent- ing individuals following protocols approved by the hospital institutional review boards, Beth Israel Deaconess Medical Center, and Harvard Medical School, Boston 02215, USA |
| Site of Infection | None |
| Opportunistic invasive | None |
| Sample type | Body fluid |
| Sample source | Blood |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | CD4 |
| Biomarker Full Name | CD4 |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | USA |
| Cohort | The clinical characteristics of the 22 adults identified with active PCP were studied. A total of 149 adults were recruited as control subjects. |
| Cohort No. | 22 Patients and 149 control |
| Age Group | 53-79 |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Pneumocystis carinii pneumonia (PCP) remains a well-recognized complication in certain groups of immunocompromised patients generally with underlying T-lymphocyte disorders. HIV infection represents a very high-risk group, in which 75% of persons may develop PCP in the absence of chemoprophylaxis. For this high-risk group, how- ever, chemoprophylaxis for PCP is not initiated until there is a measured decline in the peripheral CD4 T-lymp. |
| Technique | Immunological assay |
| Analysis Method | Immunological assay |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | Immunological assay |
| Up Regulation Down Regulation | Positive |
| Sequence Data | None |
| External Link | None |
