| DB ID | MyCo_3957 |
| Title | Jorge Lobo's disease: immunohistochemical characterization of dendritic cells in cutaneous lesions |
| Year | 2014 |
| PMID | 25487975 |
| Fungal Diseases involved | Jorge Lobo’s disease |
| Disease | Jorge Lobo’s disease |
| Associated Medical Condition | None |
| Genus | Lacazia |
| Species | loboi |
| Organism | Lacazia loboi |
| Ethical Statement | None |
| Site of Infection | Unspecified |
| Opportunistic invasive | None |
| Sample type | Biopsy |
| Sample source | Extracted Tissue |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | S100 protein |
| Biomarker Full Name | S100 protein |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | Brazil |
| Cohort | Forty-one skin biopsies from patients with clinical and histopathologic diagnosis of JLD were selected from the files of the Nu ´cleo de Medicina Tropical, Univer- sidade Federal do Para, Belem, PA, Brazil. Ten biopsies from normal skin were used as control. |
| Cohort No. | 41 Patients and 10 control |
| Age Group | None |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Jorge Lobo’s disease (JLD) is a cutaneous chronic granulomatous disease caused by the pathogenic fungus Lacazia loboi. It is usually characterized by lesions predominantly on the ears and upper and lower limbs. The disease is described in several Latin American countries, but the largest number of cases is in Brazil’s Amazon region. |
| Sub Technique | Histology |
| Technique | Instrument-based |
| Analysis Method | Immunohistochemistry analysis |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | Immunohistochemistry analysis |
| Up Regulation Down Regulation | Positive |
| Sequence Data | None |
