| DB ID | MyCo_3957 |
| Title | KL-6 as a serologic indicator of Pneumocystis carinii pneumonia in immunocompromised hosts |
| Year | 1998 |
| PMID | 9617869 |
| Fungal Diseases involved | Pneumocystis carinii pneumonia |
| Associated Medical Condition | None |
| Genus | Pneumocystis |
| Species | carinii |
| Organism | Pneumocystis carinii |
| Ethical Statement | None |
| Site of Infection | None |
| Opportunistic invasive | None |
| Sample type | Body fluid |
| Sample source | Serum |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | KL-6 |
| Biomarker Full Name | KL-6 |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | Osaka |
| Cohort | Patient 1 was a 56-year-old woman with rheumatoid arthritis treated with immunosuppressive drugs and corticosteroids. Patient 2 was a 59-year-old man with a glioblastoma who received anti-cancer drugs and corticosteroids. |
| Cohort No. | 2 |
| Age Group | 56-59 |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Pneumocystis carinii pneumonia (PCP) is a life-threatening opportunistic infection associated with suppressed cellular immunity in patients with acquired immunodeficiency syndrome (AIDS) and anti-cancer and immunosuppressive therapy. Pulmonary infection with P. carinii is associated with histologic findings of interstitial pneumonitis and irreversible fibrotic changes. KL-6, a human MUCImucin, has been reported to be a sensitive serum markerfor interstitial pneumonitis. Here we evaluated the usefulness of serum KL-6 as a marker for the development of PCP in immunocompromised hosts. |
| Technique | Immunological assay |
| Analysis Method | Immunohistochemical analysis |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | Immunohistochemical analysis |
| Up Regulation Down Regulation | Increase |
| Sequence Data | None |
| External Link | None |
