| DB ID | MyCo_3441 |
| Title | Increased peripheral blood TCD4+ counts and serum SP-D levels in patients with chronic paracoccidioidomycosis, during and after antifungal therapy |
| Year | 2017 |
| PMID | 29091134 |
| Fungal Diseases involved | Paracoccidioidomycosis |
| Associated Medical Condition | None |
| Genus | Paracoccidioides |
| Species | brasiliensis |
| Organism | Paracoccidioides brasiliensis |
| Ethical Statement | The study was approved by the local ethics committee (#283/2009-CEP). All the patients were informed of the purpose of the study, and written informed consent was obtained from all the participants. |
| Site of Infection | None |
| Opportunistic invasive | None |
| Sample type | Body fluid |
| Sample source | Serum |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | TCD4+ |
| Biomarker Full Name | TCD4+ |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | Brazil |
| Cohort | Eighty-seven PCM patients from the Tropical Diseases Ward and the Systemic Mycoses Outpatient Clinic of the University Hospital, Botucatu Medical School, São Paulo State University, were studied. Patients in whom the clinical manifestations were compatible with PCM were considered as either confirmed cases or probable cases. |
| Cohort No. | 87 |
| Age Group | None |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Paracoccidioidomycosis (PCM) is a systemic and granulomatous mycosis caused by thermally dimorphic fungi of the genus Paracoccidioides, and is characterised by antigen-dependent immunosup- pression. Incidences of PCM are con- fined to Latin America, and are especially prevalent in Brazil, Colombia, and Venezuela, predominantly among rural workers (Shikanai-Yasuda et al. 2006). The active disease presents as two main clinical forms - the acute/ subacute form (AF) and the chronic form (CF). Patients with the AF are typically children, teenagers, and young adults; they present a history of a short duration (two months in median length) and exhibit clinical manifes-tations characterised by the involvement of organs, such as the lymph nodes, bone marrow, liver, and spleen. |
| Technique | Analytic |
| Analysis Method | Flow Cytometry Analysis |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | Flow Cytometry Analysis |
| Up Regulation Down Regulation | Positive |
| Sequence Data | None |
| External Link | None |
