| DB ID | MyCo_3410 |
| Title | Role of the mannose receptor in a murine model of Cryptococcus neoformans infection |
| Year | 2008 |
| PMID | 18391001 |
| Fungal Diseases involved | Cryptococcus neoformans infection |
| Associated Medical Condition | None |
| Genus | Cryptococcus |
| Species | neoformans |
| Organism | Cryptococcus neoformans |
| Ethical Statement | Mice were specific pathogen free, and the studies were approved by the respective Institutional Animal Care and Use Committees. |
| Site of Infection | None |
| Opportunistic invasive | Opportunistic |
| Sample type | Biopsy |
| Sample source | Extracted Lungs Tissue |
| Host Group | Animal |
| Host Common name | Mice |
| Host Scientific name | Mus musculus |
| Biomarker Name | MR |
| Biomarker Full Name | Mannose Receptor |
| Biomarker Type | Negative |
| Biomolecule | Protein |
| Geographical Location | USA |
| Cohort | C57BL/6 mice were obtained from Jackson Laboratories (Bar Harbor, ME). MR (CD206) knockout (MR KO) mice were a gift from M. C. Nussenz- weig (The Rockefeller University, New York, NY) (14) and were backcrossed to a C57BL/6 background for at least 10 generations. |
| Cohort No. | None |
| Age Group | None |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Cryptococcus neoformans is an opportunistic fungal patho-gen which preferentially afflicts immunocompromised persons particularly those with AIDS or lymphoid malignancies and recipients of immunosuppressive treatments for solid organ transplants. The primary site of infection is generally the lungs. While exposure is thought to be common, most immu- nocompetent persons are able to contain the infection. How- ever, in the absence of effective CD4 T-cell responses, the organism can disseminate and eventually cross the blood-brain barrier to produce cryptococcal meningitis |
| Technique | Analytic |
| Analysis Method | Flow Cytometry Analysis |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | Flow Cytometry Analysis |
| Up Regulation Down Regulation | Negative |
| Sequence Data | None |
| External Link | None |
