| DB ID | MyCo_3212 |
| Title | Invasive fungal infections amongst patients with acute-on-chronic liver failure at high risk for fungal infections |
| Year | 2018 |
| PMID | 30276951 |
| Fungal Diseases involved | Invasive candidiasis |
| Associated Medical Condition | Acute‐on‐chronic liver failure |
| Genus | Candida |
| Species | spp. |
| Organism | Candida spp. |
| Ethical Statement | The study was approved by Post Graduate Institute of Medical Education and Research, Chandigarh Intramural Ethics Committee (Reference number NK/4566/study/831). |
| Site of Infection | None |
| Opportunistic invasive | Invasive |
| Sample type | Body fluid |
| Sample source | Serum |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | BDG |
| Biomarker Full Name | 1-3-beta-D-Glucan |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | India |
| Cohort | This study was a single centre, retrospective analysis of pa-tients with ACLF (European Association for the Study of Liver Diseases; EASL definition) and clinical suspicion of IFI, admit- ted in Liver Intensive Care Unit (LICU) at Postgraduate Institute of Medical Education and Research, Chandigarh a tertiary care research hospital in India between 2 January and 31 December 2016. Out of 264 patients with ACLF, 54 (20.4%) patients with suspicion of IFI were evaluated and IFI was diagnosed in 39 (14.7%). Invasive candidiasis was documented in 25 (64.1%) and invasive aspergillosis in 14 (35.8%). |
| Cohort No. | 25 |
| Age Group | None |
| P Value | p=0.009 |
| Sensitivity | 0.974 |
| Specificity | 0.6 |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | None |
| Technique | ELISA |
| Analysis Method | FDA Approved-Fungitell assay |
| ELISA kits | ELISA Kit- Platelia Aspergillus; Bio‐Rad laboratories, Marnes‐la- Coquette, France |
| Assay Data | FDA- Fungitell®, Cape Cod International, Inc.; Falmounth, MA, USA |
| Validation Techniques used | FDA Approved-Fungitell assay, FDA Approved -Platelia Aspergillus Ag ELISA |
| Up Regulation Down Regulation | Positive |
| Sequence Data | None |
| External Link | None |
