| DB ID | MyCo_2981 |
| Title | (1,3)-β-d-glucan in cerebrospinal fluid for diagnosis of fungal meningitis associated with contaminated methylprednisolone injections |
| Year | 2014 |
| PMID | 25540391 |
| Fungal Diseases involved | Fungal Meningitis |
| Associated Medical Condition | Contaminated Methylprednisolone Acetate (MPA) Exposure |
| Genus | Aspergillus |
| Species | fumigatus |
| Organism | Aspergillus fumigatus |
| Ethical Statement | The institutional review board [St. Joseph Mercy Hospital (SJMH) (Ann Arbor, MI) and Vanderbilt University Hospital (VUH) (Nashville, TN)] at each study site approved the study protocol, with a waiver of informed consent requirements, and the study was conducted between November 2013 and February 2014. |
| Site of Infection | None |
| Opportunistic invasive | Opportunistic |
| Sample type | Body fluid |
| Sample source | Cerebrospinal fluid (CSF) |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | BDG |
| Biomarker Full Name | 1-3-beta-D-Glucan |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | USA |
| Cohort | This is a retrospective observational study of patients who received a contaminated methylprednisolone injection from one of two lots produced by the New England Compounding Center (NECC) (lot 06292012@26 or 08102012@51). All patients received their care at St. Joseph Mercy Hospital (SJMH) (Ann Arbor, MI) or Vanderbilt University Hospital (VUH) (Nashville, TN). Patients were included if a CSF specimen was available for analysis. The institutional review board at each study site approved the study protocol, with a waiver of informed consent requirements, and the study was conducted between November 2013 and February 2014. |
| Cohort No. | 233 |
| Age Group | 58 +_ 14 years |
| P Value | None |
| Sensitivity | 0.91 |
| Specificity | 0.92 |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | None |
| Technique | ELISA |
| Analysis Method | FDA Approved Assay |
| ELISA kits | None |
| Assay Data | FDA- Fungitell assay (Associates of Cape Cod Inc., East Falmouth, MA) |
| Validation Techniques used | FDA Approved Assay |
| Up Regulation Down Regulation | None |
| Sequence Data | None |
| External Link | None |
