| DB ID | MyCo_2928 |
| Title | Plasma beads loaded with Candida albicans cytosolic proteins impart protection against the fungal infection in BALB/c mice |
| Year | 2012 |
| PMID | 23044405 |
| Fungal Diseases involved | Fungal infection |
| Associated Medical Condition | None |
| Genus | Candida |
| Species | albicans |
| Organism | Candida albicans |
| Ethical Statement | The mandates approved by the Institutional Animal Ethics Committee based on the rec- ommendations of Committee for the Purpose of Control and Supervision of Experiments on Animals (CPCSEA), Government of India (registration number 332) for handling of animal was fol-lowed. |
| Site of Infection | None |
| Opportunistic invasive | Opportunistic |
| Sample type | Body fluid |
| Sample source | Plasma |
| Host Group | Animal |
| Host Common name | Mice |
| Host Scientific name | Mus musculus |
| Biomarker Name | CD80 |
| Biomarker Full Name | CD80 |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | India |
| Cohort | Inbred female BALB/c mice (4–6 weeks old), weighing 20 ± 2 g (source: Central Drug Research Institute, Lucknow) and provided with adequate water and diet ad libitum (Hindustan Lever Ltd., India) unless mentioned otherwise. |
| Cohort No. | None |
| Age Group | None |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Candida albicans (C. albicans) is an opportunistic fungal pathogen, commonly found in the human gastrointestinal tract. The ability of C. albicans to elude host’s immunological surveillance facilitates its colonization and persistence on mucosal surfaces, leading to superficial, cutaneous and mucocutaneous Candida infections. The ability of C. albicans to switch reversibly from uni-cellular yeast into filamentous form is thought to play a key role in its establishment and pathogenecity in the host. During the last two decades, the morbidity and mortality due to systemic Candida infection has increased remarkably. The prevalence of disseminated candidiasis has been directly associated with use of intravascular catheters, broad-spectrum antibiotics, surgical pro-cedures, prolonged ICU stay, and compromising immune status of the host. |
| Technique | Analytic |
| Analysis Method | FACS Analysis |
| ELISA kits | BD Biosciences (India) ELISA assay kit |
| Assay Data | None |
| Validation Techniques used | ELISA, FACS Analysis |
| Up Regulation Down Regulation | Increase |
| Sequence Data | None |
| External Link | None |
