| DB ID | MyCo_2739 |
| Title | Esophageal candidiasis as a complication of inhaled corticosteroids |
| Year | 1997 |
| PMID | 9357379 |
| Fungal Diseases involved | Oropharyngeal candidiasis |
| Associated Medical Condition | Asthma |
| Genus | Candida |
| Species | albicans |
| Organism | Candida albicans |
| Ethical Statement | None |
| Site of Infection | Esophagus |
| Opportunistic invasive | Opportunistic |
| Sample type | Biopsy |
| Sample source | Esophageal biopsies |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | Corticosteroids |
| Biomarker Full Name | Corticosteroids |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | Michigan |
| Cohort | The patient is a 70-year-old white woman with a 20-year history of intrinsic asthma well controlled on triamcinolone acetonide 400 g, ipratropium bromide 36 g, and pirbuterol acetate 400 g, each inhaled 4 times daily. She reported no oral steroid use for at least 4 years and that she always rinsed her mouth following inhalation of triamcinolone acetonide. The patient had gastritis with peptic ulcer disease in the past and began to develop worsening upper abdominal dyspeptic pain and heartburn. Following a medication change from cimetidine to ranitidine without improvement, an esophagastroduodenoscopy was performed. |
| Cohort No. | 1 |
| Age Group | 70 |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Inhaled corticosteroids are an essential component in the anti-inflammatory treatment of asthma. Their use has allowed many patients to discontinue oral corticosteroid therapy and, therefore, significantly minimize or eliminate their well-described side effects. The side effects of inhaled corticosteroids include dryness of the mouth and throat, hoarseness, and oropharyngeal and laryngeal candidiasis. The prevalence of oropharyngeal candidiasis associated with inhaled corticosteroids has been reported to be as high as 34%. Candidal esophagitis, however, is a rare complication with only four cases reported, three of which do not document an immunologic evaluation. |
| Technique | ELISA |
| Analysis Method | ELISA based Esophagogastroduodenoscopy |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | ELISA based Esophagogastroduodenoscopy |
| Up Regulation Down Regulation | None |
| Sequence Data | None |
| External Link | None |
