| DB ID | MyCo_2680 |
| Title | Galactomannan antigen enzyme-linked immunosorbent assay for diagnosis of invasive aspergillosis after hematopoietic stem cell transplantation |
| Year | 2007 |
| PMID | 17287156 |
| Fungal Diseases involved | Invasive aspergillosis |
| Associated Medical Condition | Hematopoietic stem cell transplantation (HSCT) |
| Genus | Aspergillus |
| Species | spp. |
| Organism | Aspergillus spp. |
| Ethical Statement | None |
| Site of Infection | None |
| Opportunistic invasive | Opportunistic |
| Sample type | Body fluid |
| Sample source | Serum |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | GM |
| Biomarker Full Name | Galactomamman |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | Minnesota |
| Cohort | In 2004, all patients undergoing HSCT at the University of Minnesota Medical Center were screened with biweekly serum GM ELISAs while hospitalized. Additional testing of GM on HSCT patients outside the hospital was done as determined by clinical providers. Assays were performed on peripheral blood serum in accordance with the manufacturer’s specifi- cations (Bio-Rad, Redmond, WA). |
| Cohort No. | 121 |
| Age Group | None |
| P Value | None |
| Sensitivity | 0.005 |
| Specificity | 0.0094 |
| Positive Predictive Value | 0.0046 |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Invasive aspergillosis (IA) is a frequent and devastating complication in patients who have undergone hematopoietic stem cell transplantation (HSCT). The diagnosis of IA remains a clinical challenge. Blood, sputum, and bronchoalveolar lavage cultures have low specificity and sensitivity in detecting IA. Radiographic findings on computed tomography (CT) of the chest are also frequently nonspecific. |
| Technique | ELISA |
| Analysis Method | ELISA Based |
| ELISA kits | ELISA Kit (Bio-Rad, Redmond, WA) |
| Assay Data | None |
| Validation Techniques used | ELISA |
| Up Regulation Down Regulation | Increase |
| Sequence Data | None |
| External Link | None |
