| DB ID | MyCo_2357 |
| Title | Elevated serum levels of periostin in patients with allergic bronchopulmonary aspergillosis |
| Year | 2019 |
| PMID | 31173398 |
| Fungal Diseases involved | Allergic bronchopulmonary aspergillosis |
| Associated Medical Condition | None |
| Genus | Aspergillus |
| Species | spp. |
| Organism | Aspergillus spp. |
| Ethical Statement | This study was approved by the ethics committee of First affiliated hospital of Guangzhou Medical University, with approval number: GYFYY-2016-73. All included patients or their legal guardian signed two copies of informed consent form before study commencement. |
| Site of Infection | Lungs |
| Opportunistic invasive | Opportunistic |
| Sample type | Body fluid |
| Sample source | Serum |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | periostin |
| Biomarker Full Name | periostin |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | China |
| Cohort | This is a retrospective study. Patients’ data were screen out from the database of the First Affiliated Hospital of Guangzhou Medical University from January 2015 to December 2017. From the database, patients who were clinically diagnosed as APBA or severe allergic asthma with any sensitization were screened out based on the clinical records. Patients complicated with other active, acute or chronic pulmonary diseases (e.g. tuberculosis, COPD), severe immune diseases, heart failure, coronary heart disease or malignant tumors were excluded. Finally, a total of 43 patients were screened out from the database of the hospital. Available information of each patient were collected from the database including age, gender, results blood routine, pulmonary function, fractional exhaled nitric oxide (FeNO), imaging, skin pick test (if any), IgE (total and specific), A. fumigatus specific IgG and clinical and medication records. |
| Cohort No. | 43 Patients |
| Age Group | None |
| P Value | p< 0.01 |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Allergic bronchopulmonary aspergillosis (ABPA) is a pulmonary disease caused by Aspergillus fumigatus. The pathogenesis is owing to allergic response against A. fumigates colonizing the airways rather than saprophytic or invasive of the fungi. ABPA occurs in patients with asthma and cystic fibrosis (CF), and the prevalence of ABPA in asthma and CF is estimated to be 13% and 9% respectively. The International Society of Human and Animal Mycology (ISHAM) has concluded a detailed diagnosis criteria for ABPA, and serum total IgE level >1,000 kUA/L is one of an important experimental diagnostic indicators. Nevertheless, it remains difficult in diagnosing ABPA because a certain number of patients with ABPA exhibit serum total IgE level <1,000 kUA/L. Hartl et al. and their group have investigated indicators in ABPA patients with cystic fibrosis (CF) and concluded that thymusand activation-regulated chemokine (TARC) can be a useful biomarker in the diagnosis of ABPA in CF patients. In asthma patients however, there is still a lack of effective diagnostic markers. |
| Technique | ELISA |
| Analysis Method | ELISA Based |
| ELISA kits | ELISA Kit (R&D Systems Inc. Minneapolis, USA) |
| Assay Data | None |
| Validation Techniques used | ELISA |
| Up Regulation Down Regulation | Increase |
| Sequence Data | None |
| External Link | None |
