| DB ID | MyCo_2151 |
| Title | The impact of concomitant pulmonary infection on immune dysregulation in Pneumocystis jirovecii pneumonia |
| Year | 2014 |
| PMID | 25409888 |
| Fungal Diseases involved | Pneumocystis jirovecii pneumonia |
| Associated Medical Condition | None |
| Genus | Pneumocystis |
| Species | jirovecii |
| Organism | Pneumocystis jirovecii |
| Ethical Statement | The institutional Review Board of Taipei Veterans General Hospital approved the study (No: 201009019IC and No: 96-04-02A) |
| Site of Infection | None |
| Opportunistic invasive | None |
| Sample type | Body fluid |
| Sample source | Blood |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | IL-8 |
| Biomarker Full Name | Interleukin-8 |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | Taiwan |
| Cohort | Sixty five consecutive non-AIDS immunocompromised patients with PJP diagnosed by identification of Pneumo- cystis jirovecii cysts or trophozoites in Papanicolaou- and Gomori methenamine silver stained-smears of BALF at Taipei Veterans General Hospital from November 1987 to September 2012 were included for this study. |
| Cohort No. | 65 |
| Age Group | None |
| P Value | p=0.008 |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Pneumocystis is an opportunistic fungal pathogen that causes Pneumocystis jirovecii pneumonia (PJP). PJP-related morbidity and mortality appear to be a major health prob- lem for patients with acquired immunodeficiency syndrome (AIDS) and for those with immunosuppression resulted from chemotherapy, organ transplantation and long-term treatment with steroid or other immunosuppressants for a variety of diseases. The clinical features, radiological findings, response to treatment and outcome of PJP are reported to be widely different between the patients with or without AIDS. The reasons underlying the differences in clinical features, radiological findings, treatment response and outcome of PJP between the patients with and without AIDS remain to be elucidated. |
| Technique | ELISA |
| Analysis Method | ELISA Based |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | ELISA |
| Up Regulation Down Regulation | Increase |
| Sequence Data | None |
| External Link | None |
