| DB ID | MyCo_2146 |
| Title | Plasma IL-6/IL-10 Ratio and IL-8, LDH, and HBDH Level Predict the Severity and the Risk of Death in AIDS Patients with Pneumocystis Pneumonia |
| Year | 2016 |
| PMID | 27579328 |
| Fungal Diseases involved | Pneumocystis pneumonia |
| Associated Medical Condition | AIDS |
| Genus | Pneumocystis |
| Species | spp. |
| Organism | Pneumocystis spp. |
| Ethical Statement | The study was conducted in accordance with the 1975 Declaration of Helsinki and approved by the Ethics Committee of the First Affiliated Hospital, School of Medicine, Zhejiang University, China. |
| Site of Infection | None |
| Opportunistic invasive | Opportunistic |
| Sample type | Body fluid |
| Sample source | Plasma |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | IL-6 |
| Biomarker Full Name | Interleukin-6 |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | China |
| Cohort | A total of 32 consecutive patients (>18 years of age) diagnosed with AIDS PCP at infectious department of the First Affiliated Hospital of Zhejiang University were enrolled from March 2013 to July 2014. HIV infection was confirmed as recommended by Center for Disease Control and Prevention (CDC). |
| Cohort No. | 32 |
| Age Group | >18 |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Pneumocystispneumonia (PCP)is one of the most common opportunistic infections in HIV-infected patients with a sub-stantial mortality rate. A recent cohort study in China by Xiao et al. found that the top three most common opportunistic infections (OI) of hospitalized HIV-infected patients were tuberculosis (32.5%), candidiasis (29.3%), and PCP (2.4%), with PCP resulting in an in-hospital mortality rate of 33.1%. The incidence of PCP has declined with combination of antiretroviral therapy (ART) and PCPprophylaxis.Neverthe- less,PCPmayoccurinpatientswhoareunawareoftheirHIVinfection,areunabletoreachmedicalcare,orfailtoadhereto PCP prophylaxisorART. PCPcanalsoprogressrapidly into respiratory failure in patients not immediately treated with appropriate therapy. Early diagnosis of PCP in AIDS patientscanbechallenging,especiallywhentheCD4countis unknown; therefore, empiric therapy is often initiated based upon nonspecific clinical manifestations while awaiting the resultsofdiagnostictests. |
| Technique | ELISA |
| Analysis Method | ELISA Based |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | ELISA |
| Up Regulation Down Regulation | Increase |
| Sequence Data | None |
| External Link | None |
