| DB ID | MyCo_2050 |
| Title | Histoplasma capsulatum cell wall {beta}-glucan induces lipid body formation through CD18, TLR2, and dectin-1 receptors: correlation with leukotriene B4 generation and role in HIV-1 infection |
| Year | 2009 |
| PMID | 19299700 |
| Fungal Diseases involved | Histoplasmosis |
| Associated Medical Condition | AIDS |
| Genus | Histoplasma |
| Species | capsulatum |
| Organism | Histoplasma capsulatum |
| Ethical Statement | Experiments were approved by and conducted in accordance with guidelines of the Universidade de Sa ˜o Paulo Animal Care Committee (process no. 255/2005). |
| Site of Infection | None |
| Opportunistic invasive | Opportunistic |
| Sample type | Body fluid |
| Sample source | Human PBMC |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | β-Glucan Induced LBs |
| Biomarker Full Name | β-Glucan Induced Lipid bodies (LBs) |
| Biomarker Type | Prognostic |
| Biomolecule | Protein |
| Geographical Location | Brazil |
| Cohort | None |
| Cohort No. | None |
| Age Group | None |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Histoplasmosis is a pulmonary disease characterized by chronic granulomatosa and suppurative inflammatory reactions. The causative organism, Histoplasma capsulatum (Hc), is a dimorphic fungus with a yeast-like morphology in tissue. Infection with Hc produces a broad spectrum of dis- eases, and although the vast majority of exposed individuals recover without relapse, it may progress to life-threatening systemic disease, particularly in individuals with AIDS. |
| Technique | ELISA |
| Analysis Method | ELISA Based |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | ELISA |
| Up Regulation Down Regulation | Increase |
| Sequence Data | None |
| External Link | None |
