| DB ID | MyCo_2006 |
| Title | Cryptococcus neoformans Infection Induces IL-17 Production by Promoting STAT3 Phosphorylation in CD4+ T Cells |
| Year | 2022 |
| PMID | 35720334 |
| Fungal Diseases involved | Cryptococcus neoformans meningitis |
| Associated Medical Condition | None |
| Genus | Cryptococcus |
| Species | neoformans |
| Organism | Cryptococcus neoformans |
| Ethical Statement | This study was approved by the ethics committee of Shanghai Public Health Clinical Center, and informed consent was obtained from the participants. |
| Site of Infection | None |
| Opportunistic invasive | None |
| Sample type | Body fluid |
| Sample source | Cerebrospinal fluid (CSF) |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | IL-17 |
| Biomarker Full Name | Interleukin-17 |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | China |
| Cohort | Eleven patients with non-AIDS-associated (HIV-CM) and five patients with AIDS-associated (HIV+CM) C. neoformans meningitis and fifteen patients with TBM (drug-resistant TB) participated in this study. Nine patients with non-neurotic syphilis served as the meningitis-free disease control. |
| Cohort No. | 11 Patients and 9 control |
| Age Group | None |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Cryptococcus neoformans (C. neoformans) meningitis (CM) is a systemic and opportunistic fungal infectious disease with morbidity and mortality between 10% and 25% in medically a d v a n c e d c o u n t r i e s an d i s o f t e n d i a g n o s e d i n immunocompromised patients relevant or irrelevant to HIV/ AIDS. It contributes about 15% of AIDS-associated opportunistic infection. In recent years, more and more cases of non-AIDS-associated C. neoformans meningitis have been reported, and about 220,000 new cases and 181,000 deaths have been estimated each year. |
| Technique | ELISA |
| Analysis Method | ELISA Based |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | ELISA , Flow Cytometry Analysis, Western Blot Analysis |
| Up Regulation Down Regulation | Increase |
| Sequence Data | None |
| External Link | None |
