| DB ID | MyCo_1953 |
| Title | The biological significance of TLR3 variant, L412F, in conferring susceptibility to cutaneous candidiasis, CMV and autoimmunity |
| Year | 2011 |
| PMID | 22024499 |
| Fungal Diseases involved | Chronic candidiasis |
| Associated Medical Condition | None |
| Genus | Candida |
| Species | albicans |
| Organism | Candida albicans |
| Ethical Statement | The study was conducted with the approval of the SickKids Research Ethics Board. |
| Site of Infection | None |
| Opportunistic invasive | None |
| Sample type | Body fluid |
| Sample source | Blood |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | TNFα |
| Biomarker Full Name | Tumor Necrosis Factor alpha |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | Canada |
| Cohort | Here studied fourteen patients with chronic candidiasis, recurrent infections and multiple autoimmune manifestations, carrying the TLR3 L412F mutant. |
| Cohort No. | 14 |
| Age Group | None |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | None |
| Technique | ELISA |
| Analysis Method | ELISA Based |
| ELISA kits | ELISA Kit (R&D systems, Minneapolis, MN, and USA), ELISA kit (Antigenix America, USA), ELISA Kit (eBioscience, San Diego, CA, USA) |
| Assay Data | None |
| Validation Techniques used | ELISA, Flow Cytometry Analysis |
| Up Regulation Down Regulation | Decrease |
| Sequence Data | None |
| External Link | None |
