| DB ID | MyCo_1947 |
| Title | Increased serum soluble CD14, ICAM-1 and E-selectin correlate with disease activity and prognosis in systemic lupus erythematosus |
| Year | 2000 |
| PMID | 11035437 |
| Fungal Diseases involved | Sepsis |
| Associated Medical Condition | Systemic lupus erythematosus (SLE) and Primary Sjo Ègren's syndrome (pSS) |
| Genus | Candida |
| Species | albicans |
| Organism | Candida albicans |
| Ethical Statement | None |
| Site of Infection | None |
| Opportunistic invasive | None |
| Sample type | Body fluid |
| Sample source | Serum |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | sE-selectin |
| Biomarker Full Name | Soluble E-selectin |
| Biomarker Type | Prognostic |
| Biomolecule | Protein |
| Geographical Location | Germany |
| Cohort | Sera from the following patient groups were analyzed: 33 patients with SLE ful®lling the 1982 revised ACR criteria, 11 patients with primary Sjo Ègren's syndrome (pSS) diagnosed according to Vitali et al, 35 patients admitted to an intensive care unit because of an underlying infectious disease. |
| Cohort No. | 33 |
| Age Group | None |
| P Value | p<0.001 |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Systemic lupus erythematosus (SLE) and primary Sjo Ègren's syndrome (pSS) represent distinct, but in some instances clinically and pathogenically overlapping connective tissue diseases.1,2 Both diseases are characterized by marked activation of lymphocytes including autoreactive T and B cells and the production of a variety of autoantibodies.3 In both entities, organ involvement and prognosis are frequently dependent on the degree of systemic vasculitis. |
| Technique | ELISA |
| Analysis Method | ELISA Based |
| ELISA kits | Sandwich ELISA (IBL,Hamburg Germany) |
| Assay Data | None |
| Validation Techniques used | ELISA |
| Up Regulation Down Regulation | Increase |
| Sequence Data | None |
| External Link | None |
