| DB ID | MyCo_1717 |
| Title | Human NK Cells Develop an Exhaustion Phenotype During Polar Degranulation at the Aspergillus fumigatus Hyphal Synapse |
| Year | 2018 |
| PMID | 30405602 |
| Fungal Diseases involved | Pulmonary aspergillosis |
| Associated Medical Condition | None |
| Genus | Aspergillus |
| Species | fumigatus |
| Organism | Aspergillus fumigatus |
| Ethical Statement | None |
| Site of Infection | None |
| Opportunistic invasive | Invasive/Opportunistic |
| Sample type | Body fluid |
| Sample source | Blood |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | RANTES |
| Biomarker Full Name | RANTES |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | UK |
| Cohort | None |
| Cohort No. | None |
| Age Group | None |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Pulmonary aspergillosis is a high mortality fungal infection in immunocompromised hosts. Whilst significant progress has been made with antifungal therapies, drug resistance is emerging and there is still a pressing need for novel immunotherapies to improve outcomes. Neutrophils play a primary role in host immunity during Aspergillus fumigatus germination in the lung, however studies in murine models show that recruitment of NK cells to the lungs is critical for early host defence and that NK cells are the major source of IFN-γ in the lungs during murine neutropaenic aspergillosis. |
| Technique | ELISA |
| Analysis Method | ELISA Based |
| ELISA kits | DuoSet human ELISA kits (R and D Systems) |
| Assay Data | None |
| Validation Techniques used | ELISA, Flow Cytometry |
| Up Regulation Down Regulation | Decrease |
| Sequence Data | None |
| External Link | None |
