| DB ID | MyCo_1681 |
| Title | Diagnostic markers of allergic bronchopulmonary aspergillosis in patients with severe asthma |
| Year | 2020 |
| PMID | 32246509 |
| Fungal Diseases involved | Allergic bronchopulmonary aspergillosis |
| Associated Medical Condition | Cystic fibrosis |
| Genus | Aspergillus |
| Species | spp. |
| Organism | Aspergillus spp. |
| Ethical Statement | The study protocol was approved by the Ethics Review Committee, informed consents were obtained from all the patients. |
| Site of Infection | Lungs |
| Opportunistic invasive | Opportunistic |
| Sample type | Body fluid |
| Sample source | Serum |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | IL-8 |
| Biomarker Full Name | Interleukin-8 |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | Russia |
| Cohort | Prospective study included 21 patients with ABPA, 25 patients with severe asthma with fungal sensitization (SAFS), 37 patients with severe asthma without fungal sensitization (SAwFS), and 16 healthy people. |
| Cohort No. | None |
| Age Group | None |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Allergic bronchopulmonary aspergillosis (ABPA) is a lung disease in patients with asthma or cystic fibrosis (CF) caused by chronic allergic inflammation to Aspergillus spp. antigens. The role of different immunological mediators in the formation of chronic allergic inflammation in patients with ABPA is not sufficiently explored. |
| Technique | ELISA |
| Analysis Method | ELISA Based |
| ELISA kits | ELISA Huma Reader HS by ELISA Kit (R&D Systems, Abingdon, UK), ELISA Kit (VEKTOR BEST, Novosibirsk, RF) |
| Assay Data | None |
| Validation Techniques used | ELISA, CT |
| Up Regulation Down Regulation | Increase |
| Sequence Data | None |
| External Link | None |
