| DB ID | MyCo_1628 |
| Title | Studies on pulmonary and systemic Aspergillus fumigatus-specific IgE and IgG antibodies in horses affected with chronic obstructive pulmonary disease (COPD) |
| Year | 1998 |
| PMID | 9880102 |
| Fungal Diseases involved | Bronchopulmonary aspergillosis |
| Associated Medical Condition | Chronic obstructive pulmonary disease (COPD) |
| Genus | Aspergillus |
| Species | fumigatus |
| Organism | Aspergillus fumigatus |
| Ethical Statement | None |
| Site of Infection | Lungs |
| Opportunistic invasive | Opportunistic |
| Sample type | Body fluid |
| Sample source | Bronchoalveolar lavage fluid (BALF) |
| Host Group | Animal |
| Host Common name | Horse |
| Host Scientific name | Equus caballus |
| Biomarker Name | IgE |
| Biomarker Full Name | Immunoglobulin E |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | UK |
| Cohort | 16 COPD affected (6 geldings; 9 females; median age 9.6 years; range 5±24 years) and three control (1 gelding; 2 females; median age 4.5 years, range 4±19) horses of mixed breeds were used. |
| Cohort No. | 16 |
| Age Group | None |
| P Value | p=0.02 |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Aspergillus fumigatus (Asp. f.) causes a wide spectrum of human lung diseases including allergic bronchopulmonary aspergillosis (ABPA) in patients with pre-existing allergic asthma, invasive aspergillosis and hypersensitivity reactions in patients with pre-existing cystic fibrosis. Measurement of antibodies, such as IgE and IgG levels, is an important tool for the diagnosis of many immunological diseases and measurement of serum levels of IgE and IgG antibodies specific for Asp. f. is used in the diagnosis of ABPA in humans. Chronic obstructive pulmonary disease (COPD) is the most common chronic equine respiratory disease in the Northern hemisphere where horses are stabled for long periods and are exposed to mouldy hay and straw. Susceptible horses can develop a pulmonary hypersensitivity to fungal antigens in hay or straw which is accompanied by inflammatory responses leading to airway obstruction. However, the precise pathogenesis of equine COPD remains speculative. |
| Technique | ELISA |
| Analysis Method | ELISA Based |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | ELISA, SDS-PAGE, Western blotting |
| Up Regulation Down Regulation | Increase |
| Sequence Data | None |
| External Link | None |
