MycoBiomDB – Record Details (MyCo_1577)

Biomarker Record Details

Database ID: MyCo_1577
DB IDMyCo_1577
TitleFalse positive galactomannan results in adult hematological patients treated with piperacillin-tazobactam
Year2007
PMID17604427
Fungal Diseases involvedInvasive aspergillosis
Associated Medical ConditionHematological Malignancy
GenusAspergillus
Speciesspp.
OrganismAspergillus spp.
Ethical StatementNone
Site of InfectionNone
Opportunistic invasiveOpportunistic
Sample typeBody fluid
Sample sourceSerum
Host GroupHuman
Host Common nameHuman
Host Scientific nameHomo sapiens
Biomarker NameGM
Biomarker Full NameGalactomamman
Biomarker TypeDiagnostic
BiomoleculeProtein
Geographical LocationSpain
CohortFrom September 2004 to May 2005, a cohort of 78 adult hematological cancer patients treated in the Hospital Doce de Octubre, Madrid, Spain and stratified according to the scheme of Prentice et al., were prospectively analyzed (as a routine screening twice weekly) establishing the GM index (GMI) by using the commercially available sandwich ELISA (Platelia Aspergillus) until the risk condition for developing IFI had subsided. All patients were nursed in rooms with HEPA filtration. The clinical assessment of our patients is the standardof care in tertiary hospitals, and has been described by ourgroup elsewhere.
Cohort No.78
Age GroupNone
P Valuep<0.01
Sensitivity1
Specificity0.88
Positive Predictive Value0.47
MICNone
Fold ChangeNone
PathwayNone
Disease Introduction MechanismNone
TechniqueELISA
Analysis MethodELISA Based
ELISA kitsSandwich ELISA Kit (Platelia Aspergillus, Bio-Rad, Marnes La Coquette, France)
Assay DataNone
Validation Techniques usedELISA
Up Regulation Down RegulationIncrease
Sequence DataNone
External LinkNone