| DB ID | MyCo_1437 |
| Title | HIV-Associated Cryptococcal Meningitis Occurring at Relatively Higher CD4 Counts |
| Year | 2019 |
| PMID | 30325463 |
| Fungal Diseases involved | Cryptococcal meningitis |
| Associated Medical Condition | HIV-AIDS |
| Genus | Cryptococcus |
| Species | spp. |
| Organism | Cryptococcus spp. |
| Ethical Statement | None |
| Site of Infection | None |
| Opportunistic invasive | None |
| Sample type | Body fluid |
| Sample source | Cerebrospinal fluid (CSF) |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | CCL2 |
| Biomarker Full Name | CCL2 |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | South Africa |
| Cohort | Here enrolled 736 participants from 2 prospective cohorts in Uganda and South Africa from November 2010 to May 2017. We compared participants with CD4 <50, 50–99, or ≥100 cells/μL by clinical characteristics, cerebrospinal fluid (CSF) param- eters, and 18-week survival. |
| Cohort No. | 736 |
| Age Group | None |
| P Value | p< .01 |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Cryptococcal meningitis is responsible for 15% of AIDS-related mortality and 75% of deaths attributed to cryptococcosis in 2014 were in sub-Saharan Africa. Cryptococcosis typically occurs in human immunodeficiency virus (HIV)-infected indi-viduals with profound immunosuppression caused by quanti- tative depletion and functional abnormalities of CD4+ T cells. Dysregulation of T helper (Th) cells with high expression of the Th2 phenotype compared to Th1 phenotype appears to contribute to the pathogenesis of cryptococcosis in murine models. Alternatively activated macrophages develop in response to Th2 cytokine stimulation and result in uncontrolled cryptococcosis. |
| Technique | Analytic |
| Analysis Method | CSF Parameters analysis |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | CSF Parameters analysis |
| Up Regulation Down Regulation | Decrease |
| Sequence Data | None |
| External Link | None |
