| DB ID | MyCo_1352 |
| Title | Pneumocystis pneumonia in non-HIV children: a 10-year retrospective study |
| Year | 2016 |
| PMID | 26878193 |
| Fungal Diseases involved | Pneumocytis pneumonia |
| Associated Medical Condition | None |
| Genus | Pneumocystis |
| Species | jirovecii |
| Organism | Pneumocystis jirovecii |
| Ethical Statement | This study was approved by Medical Ethics Committee of Beijing Children’s Hospital. Due to the retrospective nature of the study, informed written consent was waived. Patients’ information was anonymized and de-identified prior to analysis. |
| Site of Infection | None |
| Opportunistic invasive | None |
| Sample type | Body fluid |
| Sample source | Bronchoalveolar lavage fluid (BALF) |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | CD4/CD8 |
| Biomarker Full Name | CD4/CD8 |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | China |
| Cohort | A total of 60 non-HIV children diagnosed with PCP were included in the study. Here selected 120 children who underwent BAL for the diagnosis of PCP during the study period as control subjects. |
| Cohort No. | 60 Patients and 120 control |
| Age Group | <15 |
| P Value | None |
| Sensitivity | 0.892 |
| Specificity | 0.804 |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Pneumocystis pneumonia (PCP), caused by Pneumo- cystis jirovecii, is a major cause of morbidity and mor- tality in patients with acquired immunodeficiency syndrome (AIDS). In recent years, the incidence of PCP in HIV patients has decreased largely due to the use of routine prophylaxis in susceptible populations. However, PCP has been increasingly reported in non-HIV patients who are immunocompromised as a result of glucocorticoid therapy and other immuno- suppressive agents, allogeneic hematopoietic stem cell transplantation, solid organ transplantation and congenital immunodeficiency syndromes. |
| Technique | Analytic |
| Analysis Method | CD4/CD8 ratio analysis |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | CD4/CD8 ratio analysis |
| Up Regulation Down Regulation | Decrease |
| Sequence Data | None |
| External Link | None |
