| DB ID | MyCo_1324 |
| Title | Combination of Candida biomarkers in patients receiving empirical antifungal therapy in a Spanish tertiary hospital: a potential role in reducing the duration of treatment |
| Year | 2015 |
| PMID | 26311840 |
| Fungal Diseases involved | Invasive candidiasis |
| Associated Medical Condition | None |
| Genus | Candida |
| Species | albicans |
| Organism | Candida albicans |
| Ethical Statement | The study was approved by the local ethics committee (CEIC-A1, ref. 247/ 13) and the Spanish Agency for Medicines and Health Care Products (Agencia Espan ˜ ola del Medicamento y Productos Sanitarios, AEMPS). |
| Site of Infection | None |
| Opportunistic invasive | Invasive |
| Sample type | Body fluid |
| Sample source | Serum |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | CAGTA |
| Biomarker Full Name | Candida albicans germ tube antibody (CAGTA) |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | Spain |
| Cohort | This was a prospective observational study including adults starting empirical antifungal treatment for suspected IC, at Gregorio Maran ˜ o ´ n Hospital, Madrid (Spain). Patients were stratified according to admission department (ICU or other wards) and final diagnosis (no IC or proven or probable IC). Type of candidiasis (candi- daemia or deep-seated candidiasis) was also considered. Sixty-three ICU patients and 37 non-ICU patients were included. |
| Cohort No. | 63 Patients and 32 control |
| Age Group | 60.8±15.7 |
| P Value | None |
| Sensitivity | 0.6 |
| Specificity | 0.857 |
| Positive Predictive Value | 0.643 |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | None |
| Technique | Immunological assay |
| Analysis Method | C. albicans germ tube antibody (CAGTA) assay (Vircell) |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | CAGTA assay,FDA Approved-Fungitell assay |
| Up Regulation Down Regulation | Positive |
| Sequence Data | None |
| External Link | None |
