| DB ID | MyCo_1269 |
| Title | Phylogenetic Distribution of csp1 Types in Aspergillus fumigatus and Their Correlates to Azole Antifungal Drug Resistance |
| Year | 2021 |
| PMID | 34787484 |
| Fungal Diseases involved | Invasive aspergillosis |
| Associated Medical Condition | None |
| Genus | Aspergillus |
| Species | fumigatus |
| Organism | Aspergillus fumigatus |
| Ethical Statement | None |
| Site of Infection | None |
| Opportunistic invasive | None |
| Sample type | None |
| Sample source | None |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | csp1 |
| Biomarker Full Name | Csp1 |
| Biomarker Type | Diagnostic |
| Biomolecule | Gene |
| Geographical Location | Germany |
| Cohort | A total of 122 isolates were taken from cryostocks prepared during a previous study. Cells were cultured in 5 ml liquid Sabouraud’s medium (bioMérieux) at room temperature on a turning wheel. DNA was prepared using beating of the cells with glass beads in a FastPrep FP120 machine in phenol-chloroform at speed setting 4 for 30 s. |
| Cohort No. | 122 |
| Age Group | None |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Apergillus fumigatus is a ubiquitously distributed saprophytic mold and a leading cause of invasive aspergillosis in human hosts. Invasive aspergillosis is mainly associated with immunocompromising conditions such as neutropenia, solid organ transplantation, hematopoietic stem cell transplantation, chemotherapy, or as a secondary infection to tuberculosis, in uenza (1), or lately COVID-19 (2, 3). Invasive aspergillosis is per se a dif cult-to-treat condition in already weakened patients. Most worryingly, pandemic azole resistant strains have emerged, which can further complicate treatment. |
| Technique | Bioinformatics analysis |
| Analysis Method | Genome SNP-based clustering analysis |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | Sanger sequencing, Whole Genome Sequencing, Genome SNP-based clustering analysis |
| Up Regulation Down Regulation | Positive |
| Sequence Data | None |
| External Link | None |
