| DB ID | MyCo_1169 |
| Title | Clinical utility of serum beta-D-glucan and KL-6 levels in Pneumocystis jirovecii pneumonia |
| Year | 2009 |
| PMID | 19218768 |
| Fungal Diseases involved | Pneumocystis jirovecii pneumonia |
| Associated Medical Condition | HIV-AIDS |
| Genus | Pneumocystis |
| Species | jirovecii |
| Organism | Pneumocystis jirovecii |
| Ethical Statement | This study was approved by the institu- tional review board for clinical research in the University of the Ryukyus. |
| Site of Infection | None |
| Opportunistic invasive | None |
| Sample type | Body fluid |
| Sample source | Bronchoalveolar lavage fluid (BALF) |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | BDG |
| Biomarker Full Name | 1-3-beta-D-Glucan |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | Okinawa |
| Cohort | For this study, consecutive 35 patients diagnosed with PCP, 19 with HIV-related PCP and 16 with non-HIV PCP, in our institution between 1989 and 2006 were retrospec- tively evaluated. |
| Cohort No. | 35 |
| Age Group | None |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Pneumocystis jirovecii pneumonia (PCP) is a major cause of morbidity and mortality in patients with human immu- nodeficiency virus (HIV) infection (HIV-related PCP) and other conditions associated with immunosuppressive therapy. Invasive diagnostic techniques such as bronchoalveolar lavage (BAL) or transbronchial lung biopsy (TBLB) and specific staining of cyst and/or trophozoites are the gold standard for PCP diagnosis. New techniques such as the identification of P. jirovecii DNA by polymerase chain reac- tion (PCR) from expectorated and induced sputa showed greater sensitivity for PCP diagnosis than conventional his-tochemical staining techniques. |
| Technique | Assay |
| Analysis Method | KL-6 antibody kit (ED046; Eisai Co., Tokyo, Japan), BDG-G test Kit (Seikagaku Corpo- ration, Tokyo, Japan), |
| ELISA kits | KL-6 antibody kit (ED046; Eisai Co., Tokyo, Japan), BDG-G test Kit (Seikagaku Corpo- ration, Tokyo, Japan), |
| Assay Data | None |
| Validation Techniques used | BDG-G test, ELISA |
| Up Regulation Down Regulation | Positive |
| Sequence Data | None |
| External Link | None |
