This is the description page for protein involved in FluSPred for the prediction of the zoonotic host tropism of the Influenza A virus with the help of its protein sequences. The table underneath provides the result in the four columns, where first columns presents the Protein Name, second column gives the segment from which it is encoded, third column provides the length of the protein, and fourth column exhibits the detailed description of the protein.
Click on the headers to sort them accordingly.
| Protein Name | Encoded from | Amino Acid Residues | Description |
|---|---|---|---|
| Polymerase Acidic Protein(PA) | Segment 3 | 716 | Protease part of RNA-dependent RNA Polymerase. |
| Polymerase Basic Protein 1 (PB1) | Segment 2 | 757 | Endonuclease part of RNA-dependent RNA Polymerase. Also plays a role in RNA elongation. |
| Polymerase Basic Protein 2 (PB2) | Segment 1 | 759 | Subunit of RNA-dependent RNA Polymerase. Recognizes mRNA cap. Also plays an important role in host tropism as single glutamic acid residue at position 627 in avian strains gets replaced by lysine, which allows replication of the virus in humans. |
| Haemagglutinin (HA) | Segment 4 | 550 | Surface glycoprotein. Plays an important role in host tropism as sialic acid receptors present in host cells bind with HA proteins at the surface of the viral envelope, which then mediates the internalization of the virus. α2,6-sialic acid linkages are recognized by human strains whereas avian strains recognize α2,3-sialic acid linkages. |
| Nucleoprotein (NP) | Segment 5 | 498 | RNA binding protein that coats the polymerases. Regulation of nuclear import. |
| Neuraminidase (NA) | Segment 6 | 454 | Surface glycoprotein with sialidase activity. |
| Matrix Protein 1 (M1) | Segment 7 | 252 | Nuclear import regulation |
| Matrix Protein 2 (M2) | Segment 7 | 97 | Ion-channel protein, which is also present in the envelope as spikes. Virus uncoating and assembly. |
| Non-Structural Protein 1 (NS1) | Segment 8 | 230 | Suppresses the production of host mRNA |
| Non-Structural Protein 2 (NS2) | Segment 8 | 121 | Nuclear export |
| PB1F2 | Segment 2 | 90 | Non-structural protein encoded by the segment which encodes PB1. The polymerase synthesizes capped RNA-primed mRNA. |
| PB1-N40 | Segment 2 | 718 | Coatomer component |
| PA-N155 | 11th inframe AUG codon in PA mRNA Segment 3 | 562 | N-terminally truncated form of PA protein. Shows no polymerase activity when expressed with PB1 and PB2. |
| PA-N182 | 13th inframe AUG codon in PA mRNA Segment 3 | 535 | N-terminally truncated form of PA protein. Shows no polymerase activity when expressed with PB1 and PB2. |
| PAX | Segment 3 | 252 | Modulates host immune response |