ECDB-Endometrial cancer gene database

REFERENCES

Gene Name	Gene ID	Pubmed ID	Classification	Mechanism	Marker	Type	Normal Cases	Disease Cases	Age	Mean Age	Place	FIGO	Grade	Remark	Title	Journal	Volume	Year
ZEB1	6935	18487993	-	-	Biomarker	-	-	88	33 to 88	60	University of Colorado Health Sciences Center; Department of Pathology	-	-	[1] ZEB1 may be a biomarker of aggressive endometrial cancers at high risk of recurrence. It may help identify women who would most benefit from chemotherapy. Furthermore; if expression of ZEB1 in type II endometrial cancers could be reversed; it might be exploited as therapy for these highly aggressive tumors. [2] The median expression of ZEB1 was significantly higher in cancer-associated stroma (median score 180); compared to hyperplasia (median score 100); or normal endometrium (median score 10) (P<0.001). There was also a significant difference in the expression of ZEB1 between hyperplasia and normal endometrium (P<0.001). [3] In both human endometrial cancer specimens and cell lines; that when ZEB1 is inappropriately expressed in epithelial-derived tumor cells; E-cadherin expression is repressed; and that this inverse relationship correlates with increased migratory and invasive potential. Forced expression of ZEB1 in the nonmigratory; low-grade; relatively differentiated Ishikawa cell line renders them migratory.	ZEB1 expression in type I vs type II endometrial cancers: a marker of aggressive disease.	Modern Pathology	21(7):912-23	2008
ZEB1	6935	17043662	-	Down regulation/ Down expression	-	-	29	55	36 to 82 (disease); 38 to 85 (control	55.5 (disease); 52.8 (control)	"Department of Obstetrics and Gynaecology	The Chinese University of HingKong	Prince of Wales Hospital."	-	-	[1] This investigation suggests that this gene is differently regulated by -4.18 fold change in the pathogenesis of endometrial carcinoma.	Identification of molecular markers and signaling pathway in endometrial cancer in Hong Kong Chinese women by genome-wide gene expression profiling	0