ECDB-Endometrial cancer gene database

REFERENCES

Gene Name	Gene ID	Pubmed ID	Classification	Mechanism	Marker	Type	Normal Cases	Disease Cases	Age	Mean Age	Place	FIGO	Grade	Remark	Title	Journal	Volume	Year
VEGFA	7422	10381125	-	Down regulation/ Down expression	-	-	-	71	31 to 76	-	Department of Obstetrics and Gynecology; Gifu University School of Medicine.	-	-	[1] The levels of VEGF (VEGF165 and VEGF121) protein and mRNA were in a wide range and higher in normal uterine endometria than in the malignant counterparts. The levels of VEGF protein were higher in order of histopathological differentiation (normal uterine endometrium > well-differentiated (G1) > moderately differentiated (G2) and poorly differentiated (G3)) and those of VEGF protein and VEGF121 mRNA were lower in order of the advance of clinical stages (normal uterine endometrium > stage I > stage II > stages III and IV). [2] ownregulated during uterine endometrial cancer progression with dedifferentiation. Namely; VEGF in some endometrial cancers might contribute to the early process of advancing of malignancy via angiogenic activity.	Expressions of vascular endothelial growth factor (VEGF) and its mRNA in uterine endometrial cancers.	Cancer Letters	134(1):15-22	1998