ECDB-Endometrial cancer gene database

REFERENCES

Gene Name	Gene ID	Pubmed ID	Classification	Mechanism	Marker	Type	Normal Cases	Disease Cases	Age	Mean Age	Place	FIGO	Grade	Remark	Title	Journal	Volume	Year
TYMS	7298	19190136	-	-	-	-	-	-	30 to 69	-	-	-	-	[1] Genetic polymorphisms in the TYMS gene may play a role in the development of endometrial cancer among Chinese women. [2] The SNP rs3819102; located in the 3'-flanking region of the TYMS gene and in an intron of the ENOSF1 gene; was associated with risk of endometrial cancer. The odds ratio (95% confidence interval) for the CC genotype was 1.5 (1.0-2.2) compared with the TT genotype. Haplotype TTG in block 2 of the TYMS gene; which includes SNPs rs10502289; rs2298583; and rs2298581 (located in introns of the ENOSF1 gene); was associated with a marginally significant decrease in risk of endometrial cancer under the dominant model (odds ratio; 0.8; 95% confidence interval; 0.6-1.0).	Association of thymidylate synthase gene with endometrial cancer risk in a Chinese population.	Cancer epidemiology; biomarkers & prevention	18(2):579-84	2009