ECDB-Endometrial cancer gene database

REFERENCES

Gene Name	Gene ID	Pubmed ID	Classification	Mechanism	Marker	Type	Normal Cases	Disease Cases	Age	Mean Age	Place	FIGO	Grade	Remark	Title	Journal	Volume	Year
SULT1A1	6817	18318428	Endometrioid Adenocarcinoma (137) and 13 unknown.	Polymorphism	-	-	165	150	44 to 83 yrs for patient; 43 to 83 yrs for control	60	Veterans Affairs Medical Center San Francisco.	I (n=70;47%); II (n=56; 37%); III (n=22; 15%); IV (n=2; 1%)	-	[1] The indviduals carrying the variants of SULT1A1 codon 213 and 2 single nucleotide polymorphism in the 3' flanking region (14A/G and 85 C/T) had an increased risk for endometrial cancer. The frequencies of G-A-C and A-G-T haplotypes of these three variants were higher in endometrial cancer patients (p<0.001; p=0.0002). [2] The frequency of combined genotypes (SULT1A1 213 GA+AA and CYP1A1 m1 TT) was higher in endometrial cancer patients (OR; 4.58; 95% CI; 2.35-8.93). [3] The combined association of CYP1A1 and SULT gene polymorphism in endometrial cancer suggest a decreased SNP of CYP1A1 and an increased SNP for SULT1A1 and SULT1E1 genes may be risk for endometrial cancer in Caucasians.	CYP1A1; SULT1A1; and SULT1E1 polymorphisms are risk factors for endometrial cancer susceptibility.	Cancer	112(9):1964-73	2008