ECDB-Endometrial cancer gene database

REFERENCES

Gene Name	Gene ID	Pubmed ID	Classification	Mechanism	Marker	Type	Normal Cases	Disease Cases	Age	Mean Age	Place	FIGO	Grade	Remark	Title	Journal	Volume	Year
SOX2	6657	20814443	-	Hypermethylation	-	-	12	57	-	-	Department of Pathology; Queen Mary Hospital; University of Hong Kong	-	-	[1] Epigenetic mechanisms may play a crucial role on the transcriptional regulation of SOX2 and loss of SOX2 expression may be related to endometrial carcinogenesis. [2] A significant correlation between SOX2 mRNA expression and hypermethylation of SOX2 was found (P = .024). Hypermethylation of SOX2 tended to be more frequently found in type II serous or clear cell adenocarcinoma. SOX2 methylation was also significantly correlated with shorter survival of patients (P = 0.046). [3] The methylation frequency of this CpG island in 72 cases of endometrial carcinoma and 12 cases of normal endometrium was assessed by MS-PCR. Hypermethylation of the SOX2 promoter was observed in 37.5% (27/72) of endometrial carcinomas; and 8.3% (1/12) of normal endometrial tissues. Therefore; more frequent hypermethylation in SOX2 promoter in endometrial cancers than in normal endometrial tissues was observed (P = .0472).	Hypermethylation of SOX2 Promoter in Endometrial Carcinogenesis	Obstetrics and gynecology international	2010. pii: 682504	2010