ECDB-Endometrial cancer gene database

REFERENCES

Gene Name	Gene ID	Pubmed ID	Classification	Mechanism	Marker	Type	Normal Cases	Disease Cases	Age	Mean Age	Place	FIGO	Grade	Remark	Title	Journal	Volume	Year
SKP2	6502	16080017	Endometrial adenocarcinoma	Up regulation/ Over expression/High expression	-	-	20 normal endometria (8 cases of the proliferative phase and 12 cases of the secretory phase)	20 endometrial hyperplasias and 136 endometrial endometriod adenocarcinomas (76 cases of well differentiated (G1); 32 cases of moderately differentiated (G2) and 28 cases of poorly differentiated (G3) adenocarcinomas)	30 to 83	57	Kitasato University Hospital; Japan	I (n=90); II (n=16); III (n=27); IV (n=3)	1 (n=76); 2 (n=32); 3 (n=28)	[1] The skp2 level might have increased due to p27 accumulation and may be a good indicator of proliferative activity and poor prognosis. [2] The high level of skp2 expression was significantly correlated with the presence of lymph node metastasis and lymph-vascular space involvement. The LI of skp2 in endometrial carcinoma was significantly correlated with that of p27; Ki-67; cdk2; cyclin A; cyclin D1; cyclin E; p53 and PTEN. The high level of skp2 expression (LI> or =20%) was significantly correlated with the patients' poor survival.	High expression of skp2 correlates with poor prognosis in endometrial endometrioid adenocarcinoma	Journal of cancer research and clinical oncology	131(9):591-6	2005