ECDB-Endometrial cancer gene database

REFERENCES

Gene Name	Gene ID	Pubmed ID	Classification	Mechanism	Marker	Type	Normal Cases	Disease Cases	Age	Mean Age	Place	FIGO	Grade	Remark	Title	Journal	Volume	Year
SHBG	6462	17315164	-	Polymorphism	-	-	1031	1037	30 to 69	54.28 (disease); 54.41 (control)	Sanghai; China	-	-	[1] The codon 327 Asn allele in the SHBG gene may be related to a reduced risk of endometrial cancer among postmenopausal women. [2] The allele frequencies of Asn were 15.0% in cases and 17.1% in controls (P = .06). The variant Asn(327) allele was associated with a reduced risk of endometrial cancer in postmenopausal women (OR; 0.72; 95% CI; 0.55-0.93). [3] The inverse association was more pronounced among postmenopausal women who had a low body mass index (OR; 0.48; 95% CI; 0.31-0.76) or longer years of menstruation (OR; 0.64; 95% CI; 0.46-0.89).	Association of endometrial cancer risk with a functional polymorphism (Asp(327)Asn) in the sex hormone-binding globulin gene	Cancer	109(7):1296-302	2007