ECDB-Endometrial cancer gene database

REFERENCES

Gene Name	Gene ID	Pubmed ID	Classification	Mechanism	Marker	Type	Normal Cases	Disease Cases	Age	Mean Age	Place	FIGO	Grade	Remark	Title	Journal	Volume	Year
RPS6KB1	6198	15627061	Endometrioid adenocarcinoma	Up regulation/ Over expression/High expression	-	-	13	50	38 to 81	-	Municipal Onocenter; Ukraine and Institute of Oncology; Kyiv; Ukraine	I (n=9); II (n=23); III (n=9); IV (n=2)	-	[1] Overexpression of S6K1 is a characteristic feature of parenchyma and vessels of endometrial adenocarcinomas. [2] In endometrial adenocarcinoma's tissues; overexpression of S6K1 was found in cytoplasm and nuclei in 8.0% of cases. [3] Overexpression of S6K1 in endothelial cells of vessels was discovered in 58% of cases. Positive correlation has been determined between: 1) tumor stage and intensity of stromal staining for S6K1 (p = 0.027); 2) tumor differentiation grade and intensity of cytoplasm staining of cancer cells for S6K1 (p = 0.039); 3) intensity of stromal staining and vessel's staining for S6K1 (p = 0.019); 4) vessel's staining for S6K1 and staining for phS6 (p = 0.028).	Immunohistochemical analysis of S6K1 and S6K2 expression in endometrial adenocarcinomas	Experimental Oncology	26(4):287-93	2004