ECDB-Endometrial cancer gene database

REFERENCES

Gene Name	Gene ID	Pubmed ID	Classification	Mechanism	Marker	Type	Normal Cases	Disease Cases	Age	Mean Age	Place	FIGO	Grade	Remark	Title	Journal	Volume	Year
RBP1	5947	16575402	Endometrioid carcinomas + Clear + Serous adenocarcinoma	Down regulation/ Down expression	-	-	-	53 (47 endometrioid carcinomas + 2 clear + 4 serous adenocarcinoma)	45 to 79	61	Institute of Pathology of Tor Vergata University and Patho-Lab Laboratories	-	1 (n=18); 2 (n=19); 3 (n=10)	[1] Reduced CRBP-1 expression is associated with the progression of endometrial carcinoma to higher grade. [2] CRBP-1 immunodetection decreased in less differentiated carcinomas with significant differences (G1 vs G2: Po0.017; G1 vs G3: Po0.0004 and G2 vs G3: Po0.0009; respectively); [3] A progressive decrease of CRBP-1 immunoreactivity in less differentiated endometrial carcinomas; with a low or absent CRBP-1 expression in G3 endometrioid carcinomas. CRBP-1 was completely absent in serous carcinomas as well as in clear cell carcinomas. The findings suggest that CRPB-1 may represent an additional phenotypic marker for the grading of endometrial carcinomas in which other morphological parameters; including nuclear pleomorphism and/or architectural abnormalities; do not allow a univocal grading.	Cellular retinol binding protein-1 expression in endometrial hyperplasia and carcinoma: diagnostic and possible therapeutic implications	Modern Pathology	19(6):797-803	2006