ECDB-Endometrial cancer gene database

REFERENCES

Gene Name	Gene ID	Pubmed ID	Classification	Mechanism	Marker	Type	Normal Cases	Disease Cases	Age	Mean Age	Place	FIGO	Grade	Remark	Title	Journal	Volume	Year
RASSF1	11186	16619251	-	Hypermethylation	-	Tumor suppressor	-	75	-	-	National Cancer Centre; Korea	-	-	[1] RASSF1A methylation was significantly associated with microsatellite instability (MSI; p < 0.001) and also with hMLH1 methylation (p < 0.001). [2] RASSF1A methylation was more frequent in KRAS mutation-negative ECs than in KRAS mutation-positive ECs (37.7% vs 14.3%). [3] RASSF1A methylation was inversely correlated with KRAS and/or BRAF mutations (p = 0.028) in MSI-negative ECs. [4] RASSF1A promoter hypermethylation is as important as KRAS mutations in activating the RAS pathway. [5] RASFF1A hypermethylation is significnatly frequent in MSI-positive ECs than MSI-negative cancers (76.7% vs 23.3%; p<0.001). [6] MSI-positive ECs have significantly more epigenetic or genetic alterations in RASSF1A and KRAS and/or BRAF than MSI-negative ECs.	RASSF1A hypermethylation and its inverse correlation with BRAF and/or KRAS mutations in MSI-associated endometrial carcinoma	International Journal of Cancer	119(6):1316-21	2006
RASSF1	11186	17170014	-	Hypermethylation	-	-	44	44	-	-	-	-	-	[1] RASSF1A methylation was observed in a high frequency in endometrial carcinoma. RASSF1A methylation was demonstrated in 85% of endometrial carcinomas; independent of recurrence. [2] RASSF1A methylation was also observed in samples of cyclic (n = 14); hyperplastic (n = 8); and atrophic (n = 13) endometrial tissues in 21%; 50% and 38%; respectively. [3] Also the presence of K-ras mutations and RASSF1A promoter methylation were not related; either directly or inversely.	RASSF1A methylation and K-ras and B-raf mutations and recurrent endometrial cancer.	Annals of Oncology	18(3):491-7	2007
RASSF1	11186	18404674	-	-	-	-	8 (4 proliferative + 3 secretory + 1 atrophic endometrium)	63 endometrioid carcinoma + 6 serous carcinoma +10 clear cell carcinoma + 16 hyperplastic endometrium without atypia + 40 atypical complex hyperplasia	34 to 97	57.9	Department of Pathology; University of HongKong; Queen Mary Hospital	-	-	[1] Significantly; more frequent RASSF1A hypermethylation was found in Type I endometrioid carcinomas than Type II carcinomas (p = 0.049). Among endometrioid cancers; significant association between RASSF1A hypermethylation and advanced stage. Advanced stage of the carcinoma correlated with methylation of RASSF1A significantly (p= 0.037)	Hypermethylation of RAS effector related genes and DNA methyltransferase 1 expression in endometrial carcinogenesis.	International Journal of Cancer	123(2):296-302	2008