ECDB-Endometrial cancer gene database

REFERENCES

Gene Name	Gene ID	Pubmed ID	Classification	Mechanism	Marker	Type	Normal Cases	Disease Cases	Age	Mean Age	Place	FIGO	Grade	Remark	Title	Journal	Volume	Year
PRKCD	5580	17959229	Endometrioid Adenocarcinoma	Down regulation/ Down expression	-	Tumor suppressor	11	4 (proliferative phase); 3 (secretory phase); 4 (atrophic).	-	54.6	Department of Pathology; University of Colorado Health Science Centre	I (n=17); II (n=7); III (n=8); IV (n=1)	-	[1] Normal endometrium exhibited abundant nuclear and cytoplasmic staining of PKC delta confined to glandular epithelium. In endometrial tumors; decreased PKC delta expression; both in intensity and fraction of epithelial cells stained; was observed with increasing tumor grade; with PKC delta being preferentially lost from the nucleus. Consistent with these observations; endometrial cancer cell lines derived from poorly differentiated tumors exhibited reduced PKC delta levels relative to well-differentiated lines. [2] Loss of PKC delta is an indicator of endometrial malignancy and increasing grade of cancer. Thus; PKC delta may function as a tumor suppressor in endometrial cancer.	Analysis of protein kinase C delta (PKC delta) expression in endometrial tumors.	Human Pathology	39(1):21-9	2008
PRKCD	5580	18949382	-	Up regulation/ Over expression/High expression	-	-	-	-	-	-	Shandong Tumor Hospital; China	-	-	[1] The microarray study shows that this gene is up-regulated by 5.515 fold in the tumor associated endometrium.	Gene alterations in tumor-associated endothelial cells from endometrial cancer.	International Journal of Molecular Medicine	22(5):619-32	2008