ECDB-Endometrial cancer gene database

REFERENCES

Gene Name	Gene ID	Pubmed ID	Classification	Mechanism	Marker	Type	Normal Cases	Disease Cases	Age	Mean Age	Place	FIGO	Grade	Remark	Title	Journal	Volume	Year
PRKCA	5578	11371124	-	-	-	-	-	42	-	-	Section of Gynecologic Oncology; Northwestern University Medical School; Chicago	I (n=33); II (n=3); III (n=4); IV (n=1)	1 (n=11); 2 (n=16); 3 (n=15)	[1] PKCalpha and estrogen receptor alpha (ERalpha) expression are inversely related (r(s) = -0.35; P = 0.046). We report significant inverse correlations among ER/progesterone receptor (PR) expression and tumor grade (r(s) = -0.49; P = 0.001 and r(s) = -0.44; P = 0.004; respectively); ER; and depth of myometrial invasion (r(s) = -0.40; P = 0.009). [2] PKCalpha and ER expression is inversely related in endometrial cancer. PKCalpha expression may be a useful prognostic indicator in endometrial cancers.	Protein kinase C alpha expression is inversely related to ER status in endometrial carcinoma: possible role in AP-1-mediated proliferation of ER-negative endometrial cancer	Gynecologic Oncology	81(3):366-72	2001