ECDB-Endometrial cancer gene database

REFERENCES

Gene Name	Gene ID	Pubmed ID	Classification	Mechanism	Marker	Type	Normal Cases	Disease Cases	Age	Mean Age	Place	FIGO	Grade	Remark	Title	Journal	Volume	Year
PLAU	5328	11063652	-	Up regulation/ Over expression/High expression	-	-	16 (6 prolifeartive; 5 seceretory; 5 postmenopausal)	34 (30 postmenopausal+ 4 premenopausal)	-	-	Royal Women's Hospital	-	1 (n=13); 2 (n=11); 3 (n=10)	[1] uPA is significantly elevated in all clinical stages examined when compared to the normal group; with a 16-fold increase in mRNA expression in advanced stage carcinomas (P < 0.0005). The expression of uPA mRNA also increased with each progression in clinical stage. [2] Expression of uPA mRNA was significantly higher in all grades (Grade 1; P ; 0.001; Grade 2; P ; 0.005; Grade 3; P ; 0.001; Mann–Whitney U test; respectively) when compared to the normal group.	Differential mRNA expression of urokinase-type plasminogen activator; plasminogen activator receptor and plasminogen activator inhibitor type-2 in normal human endometria and endometrial carcinomas.	Gynecologic Oncology	79(2):244-50	2000