ECDB-Endometrial cancer gene database

REFERENCES

Gene Name	Gene ID	Pubmed ID	Classification	Mechanism	Marker	Type	Normal Cases	Disease Cases	Age	Mean Age	Place	FIGO	Grade	Remark	Title	Journal	Volume	Year
NDRG1	10397	18377423	-	-	-	-	40 (20 proliferative+ 20 seceretory)	103 (endometrial carcinoma) + 34 atypical hyperplasia (6 simple + 28 complex atypical hyperplasia)	32 to 81	-	Shanghai Jiatong University; Shanghai; China	I-II (n=65); III-IV (n=38)	1 (n=35); 2 (n=38); 3 (n=30)	[1] The expression of NDRG1 was up-regulated in 5/40 (12.5%); 18/34 (52.94%); and 86/103 (83.5%) normal endometrium; atypical hyperplasia; and endometrial carcinoma cases; respectively (P < 0.01); while in 6/40 (15%); 20/34 (58.82%); and 89/103 (86.41%) normal endometrium; atypical hyperplasia; and endometrial carcinoma cases; respectively. [2] Statistical analyzes demonstrated a positive correlation between NDRG1 up-regulation and PTEN down-regulation (P < 0.01). [3] Identification of changes in the NDRG1 expression may be a significant diagnostic tool for the early detection of endometrial carcinoma.	Correlation between NDRG1 and PTEN expression in endometrial carcinoma.	Cancer Science	99(4):706-10	2008