ECDB-Endometrial cancer gene database

REFERENCES

Gene Name	Gene ID	Pubmed ID	Classification	Mechanism	Marker	Type	Normal Cases	Disease Cases	Age	Mean Age	Place	FIGO	Grade	Remark	Title	Journal	Volume	Year
MTHFR	4524	9450474	-	Polymorphism	Molecular Marker	-	60	80	44 to 76	-	Department of Obsterics and Gynecology; Hospital Universtari MaternoInfantil Vall d'Hebron; Barcelona	I (n=35); II+III (n=45)	1 (n=40); 2+3 (n=40)	[1] There is an association between polymorphisms at the methylenetetrahydrofolate reductase (MTHFR) gene and susceptibility to endometrial cancer. [2] DNA analysis suggest a significantly increased endometrial cancer risk with an alanine to valine substitution at nucleotide 677 of MTHFR gene with an odds ratio of 2.8 (95% confidence interval: 1.36-6.14; P = 0.002). Moreover; the tumors from patients with the valine allele were more undifferentiated (P = 0.03).	Germ line polymorphisms in cytochrome-P450 1A1 (C4887 CYP1A1) and methylenetetrahydrofolate reductase (MTHFR) genes and endometrial cancer susceptibility	Carcinogenesis	18(12):2307-11	1997