ECDB-Endometrial cancer gene database

REFERENCES

Gene Name	Gene ID	Pubmed ID	Classification	Mechanism	Marker	Type	Normal Cases	Disease Cases	Age	Mean Age	Place	FIGO	Grade	Remark	Title	Journal	Volume	Year
LRP1	4035	11006321	-	Down regulation/ Down expression	-	-	14 (premenopausal: 6 proliferative phase; 6 secretory phase; inactive postmenopausal endometrium 2)	33 (postmenopusal 30; premenopausal proliferative phase 3)	-	-	Royal Women's Hospital	IB (n=12); IC (n=6); IIA (n=4); III (11)	1 (n=14); 2 (n=8); 3 (n=11)	[1] Expression of LRP mRNA in normal endometrium is significantly incereased in the secretory phase when compared with proliferative phase endometrium (p<0.05). The expression of LRP in all carcinomas examined is significantly reduced to about 20% of the amount in normal endometrium (p<0.05). [2] LRP expression is differently regulated in the normal endometrium during the menstrual cycle and is decreased in invasive endometrial carcinomas.	Differential expression of the alpha(2)-macroglobulin receptor and the receptor associated protein in normal human endometrium and endometrial carcinoma.	Molecular Human Reproduction	6(10):921-7	2000