ECDB-Endometrial cancer gene database

REFERENCES

Gene Name	Gene ID	Pubmed ID	Classification	Mechanism	Marker	Type	Normal Cases	Disease Cases	Age	Mean Age	Place	FIGO	Grade	Remark	Title	Journal	Volume	Year
LIMS1	3987	20714146	Atypical Endometrial Hyperplasias (n=18); Endometrioid Endometrial carcinomas (n=48).	-	-	-	23 (11 proliferative phase + 12 secretory phase)	66	22 to 60 (normal endometrium); 26 to 77 (atypical endometrial hyperplasia); 33 to 74 (endometrial cancer)	36 (normal endometrium); 40.5 (atypical endometrial hyperplasia); 56 (endometrial cancer)	First Hospital of Hebei Medical University; China	I (n=34); II (n=8); III (n=5)	1 (n=1); 2 (n=25); 3 (n=5)	[1] The PINCH expression in the stroma of cancer (71%) was significantly increased compared to either normal endometrium (17%; p < 0.0001) or atypical hyperplasia (39%; p = 0.017). [2] PINCH expression in cancer was higher in the patients with hypertension (p = 0.041) and estrogen exposure time >30 years (p = 0.021). [3] PINCH protein expression markedly increased in the tumor associated stroma in endometroid hyperplasia; especially at the invasive margin of the tumor.	PINCH protein expression in normal endometrium; atypical endometrial hyperplasia and endometrioid endometrial carcinoma.	Chemotherapy	56(4):291-7	2010