ECDB-Endometrial cancer gene database

REFERENCES

Gene Name	Gene ID	Pubmed ID	Classification	Mechanism	Marker	Type	Normal Cases	Disease Cases	Age	Mean Age	Place	FIGO	Grade	Remark	Title	Journal	Volume	Year
KRAS	3845	8467512	-	Mutation	-	-	-	-	-	-	-	I (n=56); II (n=11); III+IV (n=17)	1 (n=29); 2 (n=47); 3 (n=8)	[1] The presence of a ras mutation was inversely associated with death from disease; suggesting that this molecular feature may characterize a subset of endometrial carcinomas with a good prognosis.[2] The overall incidence of Ki-ras mutations in the hyperplasia specimens (16%) was similar to the incidence detected in carcinomas (18%); indicating that ras mutation may represent an early event in a subset of endometrial carcinomas.	Mutation of the Ki-ras protooncogene in human endometrial hyperplasia and carcinoma.	Cancer Research	53(8):1906-10	1993