ECDB-Endometrial cancer gene database

REFERENCES

Gene Name	Gene ID	Pubmed ID	Classification	Mechanism	Marker	Type	Normal Cases	Disease Cases	Age	Mean Age	Place	FIGO	Grade	Remark	Title	Journal	Volume	Year
IL11	3589	20553623	-	Up regulation/ Over expression/High expression	Diagnostic Marker	-	10 (proliferative phase)	16	34 to 88	64.4	Monash Medical Centre Melbourne; Australia	-	1 (n=5); 2 (n=5); 3 (n=6)	[1] IL11 was present in uterine flushings and was significantly higher in women with Grade 1 carcinomas compared to postmenopausal women (p < 0.05). IL11 immunostaining was significantly elevated in the endometrial tumour epithelial cells from Grade 1 and 3 compared to endometrial epithelium from postmenopausal and cycling women. IL11R alpha immunostaining intensity was increased in cancer epithelium in the Grades 1 and 2 tumours compared to epithelium from postmenopausal women. [2] pSTAT3 staining intensity was significantly higher in Grade 1 and 2 tumour epithelial cells compared to epithelial cells from cycling and postmenopausal women. [3] SOCS3 in cycling endometrium was significantly higher compared to postmenopausal and Tumour Grades 2 and 3. [4] IL11; along with its specific receptor; IL11R alpha; and downstream signalling molecules; STAT3 and SOCS3; are likely to play a role in the progression of endometrial carcinoma.	Interleukin 11 is upregulated in uterine lavage and endometrial cancer cells in women with endometrial carcinoma.	Reproductive biology and endocrinology	8:63	2010