ECDB-Endometrial cancer gene database

REFERENCES

Gene Name	Gene ID	Pubmed ID	Classification	Mechanism	Marker	Type	Normal Cases	Disease Cases	Age	Mean Age	Place	FIGO	Grade	Remark	Title	Journal	Volume	Year
HTRA3	94031	16650464	Endometrial adenocarcinoma	Down regulation/ Down expression	-	-	-	33	46 to 78	65	Monash Medical Centre; Melbourne; Australia	-	-	[1] Positive immunostaining; scored semiquantitatively; revealed a significant decrease of HTRA3 protein expression with increasing grades of EC. [2] The mRNA level of HTRA3 significantly decreased in Grade2 and Grade3 EC compared with normal human endometrium (C; mean=0.73; SEM=0.06; Grade2; P<0.05; mean=0.26; SEM=0.05; Grade3; P<0.05; mean=0.27; SEM=0.07).	Serine proteases HTRA1 and HTRA3 are down-regulated with increasing grades of human endometrial cancer.	Gynecologic Oncology	103(1):253-60	2006
HTRA3	94031	19424634	-	Down regulation/ Down expression	-	tumor suppressor	36	88	-	-	Medical University of Gdansk; Poland	I (n=64); II (n=13); III+IV (n=11)	1 (n=35); 2 (n=22); 3 (n=5)	[1] A significant decrease of HtrA3 mRNA level is observed in endometrial cancer as compared to the normal group (p=0.000). For HtrA3 a 3.2 fold decrease is observed. There is a significant correaltion between HtrA1 and HtrA3 mRNAs (r=0.541; p=0.000). HtrA1 and HtrA3 mRNA levels are lower in stage III and IV tumors compared to stage I and II. [2] Analysis of TGF-b1 and HtrA protein level showed a statistically significant negative correlation between the level of TGF-b1 and HtrA3 levels (p=0.006).	Expression of human HtrA1; HtrA2; HtrA3 and TGF-beta1 genes in primary endometrial cancer.	Oncology Reports	21(6):1529-37	2009