ECDB-Endometrial cancer gene database

REFERENCES

Gene Name	Gene ID	Pubmed ID	Classification	Mechanism	Marker	Type	Normal Cases	Disease Cases	Age	Mean Age	Place	FIGO	Grade	Remark	Title	Journal	Volume	Year
HTRA2	27429	19424634	-	Down regulation/ Down expression	-	-	36	88	-	-	Medical University of Gdansk; Poland	I (n=64); II (n=13); III+IV (n=11)	1 (n=35); 2 (n=22); 3 (n=5)	[1] A slight decrease of mRNA level in the endometrial cancers compared to normal endometrium. A significant correlation between HtrA2 and HtrA1 mRNAs (r=0.239; p=0.008) and between HtrA2 and HtrA3 mRNAs (r=0.265; p=0.003). [2] Analysis of TGF-b1 and HtrA protein level showed a statistically significant negative correlation between the level of TGF-b1 and HtrA2 levels (p=0.000).	Expression of human HtrA1; HtrA2; HtrA3 and TGF-beta1 genes in primary endometrial cancer.	Oncology Reports	21(6):1529-37	2009