ECDB-Endometrial cancer gene database

REFERENCES

Gene Name	Gene ID	Pubmed ID	Classification	Mechanism	Marker	Type	Normal Cases	Disease Cases	Age	Mean Age	Place	FIGO	Grade	Remark	Title	Journal	Volume	Year
HTRA1	5654	16650464	Endometrial adenocarcinoma	Down regulation/ Down expression	-	-	-	33	46 to 78	65	Monash Medical Centre; Melbourne; Australia	-	-	[1] Positive immunostaining; scored semiquantitatively; revealed a significant decrease of HTRA1 protein expression with increasing grades of EC. [2] The mRNA level of HTRA1 significantly decreased in all grades of EC compared with normal human endometrium (C; mean=0.601; SEM=0.011; Grade1; P<0.001; mean=0.383; SEM=0.036; Grade2; P<0.05; mean=00.47; SEM=0.023; Grade3; P<0.001; mean-0.325; SEM=0.025). There is also a decrease in HTRA1 mRNA levels from Grade2 EC to Grade3 EC(P<0.01).	Serine proteases HTRA1 and HTRA3 are down-regulated with increasing grades of human endometrial cancer.	Gynecologic Oncology	103(1):253-60	2006
HTRA1	5654	19424634	-	Down regulation/ Down expression	-	tumor suppressor	36	88	-	-	Medical University of Gdansk; Poland	I (n=64); II (n=13); III+IV (n=11)	1 (n=35); 2 (n=22); 3 (n=5)	[1] A significant decrease of HtrA1 mRNA level is observed in endometrial cancer as compared to the normal group (p=0.000). For HtrA1 a 1.8 fold decrease is observed. There is a significant correaltion between HtrA1 and HtrA3 mRNAs (r=0.541; p=0.000). HtrA1 and HtrA3 mRNA levels are lower in stage III and IV tumors compared to stage I and II.[2] Analysis of TGF-b1 and HtrA protein level showed a statistically significant negative correlation between the level of TGF-b1 and HtrA1 levels (p=0.000).	Expression of human HtrA1; HtrA2; HtrA3 and TGF-beta1 genes in primary endometrial cancer.	Oncology Reports	21(6):1529-37	2009