ECDB-Endometrial cancer gene database

REFERENCES

Gene Name	Gene ID	Pubmed ID	Classification	Mechanism	Marker	Type	Normal Cases	Disease Cases	Age	Mean Age	Place	FIGO	Grade	Remark	Title	Journal	Volume	Year
HOXA11	3207	12796396	Endometrial Adenocarcinoma	Hypermethylation	-	-	-	-	-	-	-	-	-	[1] High rates of methylation were found in the HOXA11. HOXA11 promoter methylation was significantly more frequent in recurrent than nonrecurrent cases. HOXA11 methylation in early stage endometrial cancer is associated with poor outcome.[2] The HOXA11 promoter had the highest rate of methylation; with 17 of 24 (70.8%) primary tumors and all of the cell lines showing methylation. Eleven of 12 (91.7%) recurrences and 6 of 12 (50%) nonrecurrences were methylated (P = 0.0686; Fisher’s exact test). [3] HOXA11 methylation appears to be a molecular event that can predict recurrence in stage I and II endometrioid endometrial adenocarcinoma.	Frequent HOXA11 and THBS2 promoter methylation; and a methylator phenotype in endometrial adenocarcinoma	Clinical Cancer Research	9(6):2277-87	2003