ECDB-Endometrial cancer gene database

REFERENCES

Gene Name	Gene ID	Pubmed ID	Classification	Mechanism	Marker	Type	Normal Cases	Disease Cases	Age	Mean Age	Place	FIGO	Grade	Remark	Title	Journal	Volume	Year
HDAC2	3066	20178884	-	Up regulation/ Over expression/High expression	-	-	30 (15 proliferative+ 15 secretory)	66	27 to 78	57	Shinshu University Hospital	I (n=66); II (n=9); III (n=11); IV (n=5)	1 (n=30); 2 (n=19); 3 (17)	[1] The expression of HDAC2 was significantly stronger thanthat in normal endometrial epithelia. [2] The positivity index for histone deacetylase 1 (79.8 +/- 33.0; mean +/- SD) and histone deacetylase 2 (106.3 +/- 41.9) was higher in endometrial carcinoma than the normal endometrium; with a significant difference for histone deacetylase 2. The positivity index for histone deacetylase 2 was significantly increased in higher-grade carcinomas (positivity index for grade 3; 124.9 +/- 28.4) compared with grade 1 tumors (86.0 +/- 41.0) and was positively correlated with that for Ki-67. In addition; patients with histone deacetylase 2-positive carcinomas had a poor prognosis compared with those with histone deacetylase 2-negative carcinoma (P = .048).	Immunohistochemical detection of histone deacetylases in endometrial carcinoma: involvement of histone deacetylase 2 in the proliferation of endometrial carcinoma cells	Human Pathology	41(6):848-58	2010